Wildfire-related PM2.5 and DNA methylation: An Australian twin and family study

Rongbin Xu; Shanshan Li; Yao Wu; Xu Yue; Ee Ming Wong; Melissa C Southey; John L Hopper; Shuai Li; Yuming Guo

Journal article

Wildfire-related PM2.5 and DNA methylation: An Australian twin and family study

Rongbin Xu, Shanshan Li, Yao Wu, Xu Yue, Ee Ming Wong, Melissa C Southey, John L Hopper, Shuai Li, Yuming Guo

ENVIRONMENT INTERNATIONAL | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2023

DOI: 10.1016/j.envint.2022.107704

Abstract

Background: Wildfire-related fine particulate matter (PM2.5) has many adverse health impacts, but its impacts on human epigenome are unknown. We aimed to evaluate the associations between long-term exposure to wildfire-related PM2.5 and blood DNA methylation, and whether the associations differ from those with non-wildfire-related PM2.5. Methods: We studied 479 Australian women comprising 132 twin pairs and 215 of their sisters. Blood-derived DNA methylation was measured using the HumanMethylation450 BeadChip array. Data on 3-year (year of blood collection and previous two years) average wildfire-related and non-wildfire-related PM2.5 at 0.01°×0.01° spatial resolution were created by combini..

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University of Melbourne Researchers

Melissa Southey Author

Shuai Li Author

Michael Abramson Author

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Grants

Awarded by Monash University Postgraduate Pub-lication Award, China Scholarship Council

Awarded by Australian National Health and Medical Research Council

Awarded by Victorian Cancer Agency

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

Funding This work was supported by Monash University Postgraduate Pub-lication Award, China Scholarship Council [grant number 201806010405] , Australian National Health and Medical Research Council [grant numbers APP1163693, APP1109193, APP1155163, 1050561 and 1079102] , Victorian Cancer Agency (grant number ECRF 19020) , and Cancer Australia and National Breast Cancer Foundation (grant number 509307) .